Disease directory
Stevens-Johnson Syndrome (SJS) / Toxic Epidermal Necrolysis (TEN)
Published: September 18, 2026Updated: September 18, 2026
Important: Informational content intended for healthcare professionals. It does not replace clinical evaluation or establish a doctor-patient relationship.
Overview
- Names : SJS; TEN (Lyell’s syndrome); drug-induced epidermolysis/epidermal necrolysis (EN). Lyell 1956 .
- First description : SJS by Stevens and Johnson (1922); TEN by Alan Lyell (1956). Schneider 2017 , Lyell 1956 .
- Epidemiology : Combined incidence ~1–2/million/year; approximate mortality SJS 5–10%, TEN 25–35% (varies by age/comorbidities). Harr 2010 , Hsu 2016 , Charlton 2020 .
- SCAR-BSA criteria : SJS <10% SC, SJS/TEN 10–30%, TEN >30%. Bastuji-Garin 1993 .
- Codes : ICD-10: L51.1 (SJS), L51.2 (TEN), L51.3 (SJS/TEN overlap). WHO ICD-10 SJS , WHO ICD-10 TEN , WHO ICD-10 overlap .
ICD-11 (chapter “Epidermal necrolysis syndrome”): EA80 (subcategories for SJS, SJS/TEN and TEN). ICD-11 .
- Diagnostic checklist (quick)
-
Clinical presentation : febrile prodrome, skin pain, “dusky” macules/atypical targets, flaccid blisters, mucosal erosions, SC %.
-
Classification : SJS <10% / SJS-TEN 10–30% / TEN >30%. Bastuji-Garin 1993 .
-
Laboratory tests : CBC, LFTs/RPTs, electrolytes, urea, glucose, bicarbonate, cultures if fever is present.
-
Scales : SCORTEN d1/d3. Bastuji-Garin 2000 .
-
Biopsy : punch blister edge (H&E) + perilesional for DIF if in doubt.
-
Causality : ALDEN. Sassolas 2010 .
-
Doctors who treat Stevens-Johnson Syndrome (SJS) / Toxic Epidermal Necrolysis (TEN)
Directory specialists related to Stevens-Johnson Syndrome (SJS) / Toxic Epidermal Necrolysis (TEN).
There are no specialists associated with this record yet
You can browse the full directory and filter by the condition you're interested in.
Go to directory