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Mixed cutaneous tumor (Chondroid syringoma)

Published: September 18, 2026Updated: September 18, 2026

Important: Informational content intended for healthcare professionals. It does not replace clinical evaluation or establish a doctor-patient relationship.

Overview

  • Names: Mixed cutaneous tumor, Chondroid syringoma, Pleomorphic adenoma of the skin (due to its histological similarity to pleomorphic adenoma of salivary glands) Obaidat 2007 , Wan 2018
  • History: Probably described by Nasse in 1892 as a mixed skin tumor. The term “chondroid syringoma” was proposed by Hirsch and Helwig in 1961 in a classic case series. Kallam 2013 (citing Hirsch & Helwig)
  • Epidemiology:
    • Rare adnexal tumor: approximately 0.01–0.098% of all primary cutaneous tumors. Wan 2018 , Huang 2022
    • It is most common in middle-aged adults (4th–6th decades), although cases have been described from adolescence to old age . Bedir 2016 , Wan 2018
    • Clear male predominance (≈2–4:1) in benign forms; malignant forms are described somewhat more frequently in women. Bedir 2016 , Zufall 2022
    • Typical location: head and neck (nose, upper lip, cheek, forehead, scalp, auricle, eyelids, periorbital region). Wan 2018 , Belfquih 2012 , Walvekar 2021
    • Other reported locations: trunk, lower back, extremities, lip, chin, foot, external genitalia. Huang 2022 , Anandani 2023 , Reddy 2018
  • Codes: There is no specific code for “chondroid syringoma” ; it is coded by behavior and location.
    • ICD-10 (indicative, depends on location): D23.x – Other benign skin tumors (e.g., D23.0 face / D23.3 scalp). Malignant forms: C44.x – Other malignant skin tumors (according to anatomical region).
    • ICD-11 2F3Z / “Other specified benign neoplasms of skin” + specific histological extension (e.g. XH70N8 “Chondroid syringoma” in some coding tables).
  • Diagnostic checklist (quick)
    • Essential clinic
      • Solitary , well-defined, slow-growing dermal/subcutaneous nodule, usually on the head and neck .
      • Size, time of evolution, symptoms (pain, ulceration, rapid growth).
      • Regional lymph node exploration.
    • Imaging tests (if required)
      • Cutaneous ultrasound to assess extent and solid characteristics.
      • CT/MRI in deep lesions (especially orbit and periorbital region).
    • Biopsy / specimen
      • Preferably complete excision (small) or deep biopsy including dermis and hypodermis (large/suspicious).

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