Disease directory
Localized cutaneous mucinosis
Published: September 18, 2026Updated: September 18, 2026
Important: Informational content intended for healthcare professionals. It does not replace clinical evaluation or establish a doctor-patient relationship.
Overview
- Alternative names. Localized cutaneous mucinosis (LCM) groups primary entities with dermal deposit of mucin without thyroid disease or monoclonal gammopathy; the following stand out: localized myxedomatosis lichen (LML) —subtypes: discrete papular, acral persistent papular mucinosis (APPM), nodular, papular mucinosis of childhood and self-resolving forms—, and focal cutaneous mucinosis (FCM) (separate entity with single lesion) Rongioletti 2001 , Rongioletti 2006 , Cárdenas-González 2019 .
- Historical description. LM/LML has been nosologically organized since Montgomery & Underwood (1953); MFC was described by Johnson & Helwig (1966) Montgomery 1953 , Rongioletti 2001 .
- Epidemiology. LML is rare; the APPM (acral persistent localized mucinosis) subtype predominates in middle-aged women and affects the backs of the hands and wrists; MFC is usually a solitary lesion in adults; self-resolving juvenile cutaneous mucinosis (SHJCM) is pediatric and self-limiting (Harris 2004 , Luchsinger 2018 ).
- Codes: ICD-10 L98.5 (Cutaneous mucinosis). ICD-11 EB90.11 (Lichen myxoedematosus)
- Diagnostic checklist (essential):
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History + PE: distribution (acral vs trunk), systemic symptoms (NOT in LML).
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Laboratory (LML): TSH/T4; SPEP (Serum protein electrophoresis) or IFX (Immunofixation electrophoresis) to exclude MGUS (Monoclonal gammopathy of undetermined significance).
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Adequate biopsy : deep/excisional punch; order Alcian blue pH 2.5 , colloidal iron and hyaluronidase (confirm hyaluronate).
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Assess DDx (scleromyxedema, REM/tumid, follicular mucinosis, myxoid tumors).
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