Disease directory
Dyshidrotic eczema
Published: September 18, 2026Updated: September 18, 2026
Important: Informational content intended for healthcare professionals. It does not replace clinical evaluation or establish a doctor-patient relationship.
Overview
- Definition and synonyms
- Vesiculobullous eczematous dermatosis of the palms, lateral areas of the fingers and/or soles , typically recurrent , with deep vesicles (“tapioca grains”), pruritus and subsequent desquamation. Wollina 2010 , Scotelaro-Alves 2019
- Synonyms/use in literature: pompholyx , dysidrosis (historical term), recurrent vesicular palmoplantar dermatitis (RVPD) . Scotelaro-Alves 2019
- First description
- The concept of “dysidrosis” was historically linked to sweat dysfunction/obstruction; Fox proposed this relationship and coined the term, although later it was demonstrated that there was no causal relationship with sweat glands (hence the name is a “ misnomer” ). Scotelaro-Alves 2019
- Epidemiology (practical points)
- It can occur at any age; it is frequently observed in young adults (heterogeneous global data). Coenraads 2012 , Wollina 2010
- In a pediatric/adolescent cohort with RVPD: hands affected ~ 94% , feet ~ 72% , hyperhidrosis ~ 67% , atopic factors ~ 78% (not extrapolatable 1:1 to adults, but useful as a “clinical signal”). Scotelaro-Alves 2019
- Relevant association: tinea pedis as a risk factor for vesicular eruptions on the hands (RR ~3.6 in a population study). Bryld 2003
- Codes
- ICD-10: L30.1 (dyshidrosis). (Standard administrative data; not always cited in clinical articles.)
- ICD-11: There is a specific dermatological taxonomy in ICD-11; the exact code for “dyshidrotic eczema/pompholyx” may vary depending on implementation/location and is not usually reported in clinical articles. General reference on ICD-11 dermatology: White 2022
- Diagnostic checklist (quick)
- Clinical presentation: deep vesicular pattern on palms/sides of fingers/soles; symmetry; pruritus; recurrence; progression to desquamation/fissures. Wollina 2010
- Exposures: wet work, irritants, occupation, gloves/rubber, metals, fragrances. Coenraads 2012
- Rule out tinea pedis: foot/nail examination + KOH/culture if suspected. Bryld 2003
- If chronic/refractory: patch test . Thyssen 2022
- If atypical: H&E biopsy ± DIF for bullous/psoriasis differentials. Wollina 2010
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